A real-time, reliable and reproducible way to measure VOCs in exhaled breath

  • Real-time measurement
  • Online 
  • Immediate feedback at point-of-care
  • Easy to use
  • Cost-efficient
  • Suitable for children
  • High patient safety and comfort


The scientific development of the SpiroNose has been driven by the combined efforts of the multidisciplinary team of researchers of the Amsterdam University Medical Centres headed by Prof. Dr. Peter Sterk

The SpiroNose is a technical and clinical validated integration between routine spirometry and electronic nose (eNose) technology connected in series with each other, allowing diagnosis and stratification of patients with cancer, infectious and inflammatory disease in the doctor’s office. The exhaled breath is real-time measured (<1 minute) by the SpiroNose, which is connected to a Gateway for immediate and secure data transmission to the online BreathBase server, hosted on the Microsoft Azure Western Europe data centre in Middenmeer the Netherlands for further automated analysis. BreathBase, which includes a centralised database, allows secured online sharing of the results between clinical and academic partners at multiple sites and is developed conform the requirements of the following standard: ISO 27001 (Information Security).


Easy to use

A simple measurement manoeuvre that is straightforward for participants to perform

Reliable and Reproducible

The SpiroNose is ideal for longitudinal studies that measure the complete mixture of VOCs over time


The complete mixture of VOCs in exhaled breath is real-time measured and allows for immediate feedback

Minimizes cross-contamination

Disposable single-use bacterial and viral filter, mouthpiece and nose clamp minimize risk of cross-contamination

Linked to an online platform

Immediate and secured transmission of the sensor data the online BreathBase server for further automated analysis

Immediate feedback

In combination with the BreathBase Platform and the integrated database, direct feedback at the point-of-care has become possible

How does it work?

Exhaled breath analysis by the BreathBase Solution


The participant takes a deep breath and calmly exhales through the SpiroNose. The cross-reactive sensors in the SpiroNose capture the complete mixture of VOCs in the participant’s exhaled breath.


The various sensor readings are immediately processed and corrected for the ambient air by the BreathBase Platform. The latter is necessary because the air that you exhale is influenced by the air that you inhale.


The sensors respond to the exhaled breath of the participant. All the sensors react in a different way, because each sensor has it highest sensitivity to a different group of molecules.


The obtained breath profiles are compared to the online BreathBase Data. On the basis of machine learning algorithms a final diagnostic answer will be established.


The SpiroNose consists of 7 different metal oxide semiconductor sensors

Each sensor is present in duplicate on both the inside and the outside of the SpiroNose. The SpiroNose has a total of eight circuit boards including three or four sensors. Four sensor arrays are positioned inside the tube and measure the VOCs in the participants’ exhaled breath and four sensor arrays measure the VOCs in the ambient air. On the BreathBase Platform you will have real-time access to the raw sensor values and the processed sensor values that can be used for statistical analysis.